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2021 proved to be a big year for structural biology, and Calibre Scientific is delighted to be part of such an innovative field. Below, we provide a brief overview of field developments in structural biology this year, with a focus on impactful papers that used Calibre Scientific products. Read More.


Anatrace is proud to announce their newest product line of Styrene-Maleic Anhydride Polymers (SMA). Our four, novel, modified SMA polymers are designed to form planar lipid bilayer nanodiscs, beginning with 1) SMA-EA or Styrene Maleic Acid - Ethanol Amine copolymer, sodium salt, derivatized with ethanolamine 2) SMA-ED (Styrene Maleic Acid-Ethylenediamine copolymer) SMA derivatized with ethylenadiamine 3) SMAd-A (Styrene Maleimide-Amine copolymer) Dehydrated SMA Ethylenediamine copolymer, and lastly 4) SMA-QA (Styrene Maleimide Quaternary Ammonium copolymer.

All SMA's are direct, detergent-free systems for the extraction of membrane proteins (MPs) in their natural membrane environment. Used for the reconstitution of MPs into synthetic lipid nanodiscs. Demonstrated to solubilize well-folded MPs and good for structural and functional studies of MPs. Read More.


Recently, our team at Anatrace came across two peer-reviewed articles that summarize current applications of popular detergents and surfactants in the field of structural biology and serve as excellent references for existing research. In this newsletter, we’d like to showcase these articles as abstracts and share some exciting innovations in the membrane protein research space! Read the full article.


We are amplifying our successful Anapoe® portfolio with the Anapoe® EH-9 (APEEH9). It is purified from ECOSURF™ EH-9, which is compliant with ecological regulations concerning biodegradability [4]. The product is tested to meet our high standards of less than 20µM peroxides. And we bring it at an affordable price in a variety of package sizes! Read more.


Anatrace supplies full-length trimeric spike antigens of the latest SARS CoV-2 mutant strains. All variants are full -length antigens, which are active in their natie trimeric form and stabilized in LMNG detergent. Download fact sheet.

MAY 2021

Introducing the 15 minute, single step stain. Our Quick Coomassie Protein Stain offers unrivaled performance up to 50 times more sensitive than other rapid stains and quicker than the leading competitor. Learn more.

APRIL 2021

Anatrace accompanies your protein from cell culture flask to atomic structure! We take pride in offering a wide portfolio of gold standard product lines, this is what makes us the leader in the field of structural biology. Read the full newsletter to learn more.


As we ring in the first quarter of 2021, we continue to highlight our newest edition to the Anatrace amphipol family, the Non-Ionic Amphipol (NAPol). A comprehensive background on NAPols can be found in our January 2021 Newsletter and the below abstract highlights key developments of the NAPol since their initial introduction in our August 2019 Newsletter


We are kicking off 2021 continuing to highlight amphipols promoting our newest addition to the Anatrace amphipol family, the Non-Ionic Amphipol (NAPol) introduced in our August 2019 Newsletter, use coupon code NAPol to get 10% off your next order, now through the end of April 2021!



These past months, we feature the continued growth of our parent company, Calibre Scientific, as well as well as the launch of our Anatrace COVID website. This webpage is dedicated to the development efforts around research and diagnostic tools needed in the fight against COVID-19.


This month we feature fSEC-Nb, a new method for detergent screening. fSEC-Nb, was tested on both bacterial and eukaryotic membrane proteins (including a panel of membrane proteins from SARS-CoV-2), and can be applied to both ortholog screening and thermostability assays.


In our September newsletter we highlight the exciting structural biology research on cellulose synthase enzymes being done by the lab of Jochen Zimmer at the University of Virginia. We also highlight which Anatrace detergents were used in these Cryo-EM and crystal structures.


Anatrace and our sister companies have been responding to the COVID-19 pandemic by producing a number of tools and reagents for transport of patient samples and testing kits. In this month's newsletter we highlight two of these reagents: full-length recombinant spike protein, and Guanidinium Thiocyanate (GTC).

JULY 2020

The Microlytic MCSG Suite is still one of the most productive crystallization screens available. In our July newsletter, learn about some of the recent proteins that have been crystallized using this screen. From now until the end of September, we're offering a promotion on crystallization screens and reagents from Microlytic, Molecular Dimensions, and NeXtal!

JUNE 2020

A new application for GDN beyond Cryo-EM? Our June newsletter highlights a recent publication from the lab of Martin Caffrey showing the compatibility of GDN with LCP crystallization!

MAY 2020

This month, we highlight how detergents are being used to study viral fusion proteins such as the spike protein from SARS-CoV-2 and hemagglutinin glycoprotein (HA) of the influenza virus. One detergent commonly used to study these proteins is Zwittergent 3-14, which is chemically identical to our Anzergent 3-14 detergent.

APRIL 2020

In our April, 2020 edition of our newsletter, we provide an update on how structural biology is being used to fight COVID-19.

MARCH 2020

In our March, 2020 newsletter we highlight recent examples of the use of fluorinated octyl maltoside and fluorinated fos-choline-8 to improve the vitrification process in the Cryo-EM studies of membrane proteins.


Every February we release our popular overview of the previous year's detergent usage in membrane protein structural biology. Learn which methods and detergents were most commonly used for the solubilization, purification, and structure determination of the 122 unique membrane proteins determined in 2019.


We're kicking off the year by recapping some of the highlights that rounded out 2019! In December, our parent company, Calibre Scientific announced the aquisition of the NeXtal line of crystallization products from Qiagen. Additionally, our sister company, Molecular Dimensions, is now an authorized distributor of Protochips C-flat cryo-EM grids in the Americas, Europe, and Asia!



We're excited to announce that our parent company, Calibre Scientific, has aquired the NeXtal line of crystallization screens and EasyXtal plates from Qiagen. NeXtal now joins our other structural biology companies which include Microlytic, Molecular Dimensions, and Anatrace.


In our November, 2019 newsletter we discuss different tools available for detergent screening. We're also excited to announce that the detergent panel from the Analytic Selector Kit, containing 94 unique detergents, is now available as an individual product.


Like we do each October, we are providing you with a table of the latest unique membrane protein structures determined by Cryo-EM, and the detergents used in their structure determination. Out of the 92 unique membrane protein structures determined to date in 2019, 44 have been determined using Cryo-EM!


In September, there were four new Cryo-EM structures determined using GDN (glyco-diosgenin). Learn more about our synthetic drop-in substitute for Digitonin in this month's newsletter


This month, we are excited to launch the newest member to our amphipol family: Non-Ionic Amphipol (NAPol). NAPol avoids some of the limitations of traditional amphipols, such as insolubility at low pH and in the presence of multivalent cations. NAPol is also compatible with many biophysical assays, including NMR, cell-free expression, and cryo-EM structure determination.

JULY 2019

In our July newsletter, we launched our new Biotinylated Amphipol PMAL-C8 (BP5008). Along with Biotinylated A8-35, these molecules allow for the immobilization of amphipol reconstituted membrane proteins onto solid supports

JUNE 2019

In our June newsletter, we provided a mini-review of "detergent-free" technologies including Amphipols, Nanodiscs, Salipro, and Polymers. We also launched the lipids DOPG, DMPE, POPS, DPPS, and a 3:1:1 POPC:POPE:POPG mixture for Nanodisc/Salipro reconstitution

MAY 2019

In our May newsletter, we highlight the latest trends in GPCR structural biology and present which expression systems, detergents, and methods are most commonly used. Additionally, we highlight the latest tools from Anatrace and Molecular Dimensions for LCP crystallization.

APRIL 2019

In our April newsletter, we highlight research from the Francis Crick Institute in London where the detergent MNA-C12 was used in the recent Cryo-EM structure of the influenza hemagglutinin protein.

MARCH 2019

This month, we are excited to launch our newest host lipid for LCP crystallization: 7.7 MAG. With a smaller bilayer thickness and larger solvent channel, the cubic phase formed by 7.7 MAG is thought to support crystallization of membrane proteins with larger intra and extracellular domains.


Each year, we pause to reflect on the previous year’s detergent usage within membrane protein structural biology. And it’s been a fascinating year, to say the least, as more than 100 unique structures were determined. Find out which detergents were commonly used for the solubilization, purification, and structure determination of membrane proteins in this month's newsletter!


In our first newsletter of 2019, we highlight the incredible structure of the Membrane Attack Complex (MAC) published by the lab of Doryen Bubeck in Nature Communications. Anatrace is excited to have provided the lipids and detergents used in this study!

2018 Newsletter Graphic  


We are celebrating all that has been accomplished this past year in membrane protein science. More than 100 unique membrane protein structures were deposited, many of which used Anatrace tools in their structure determination process. We also celebrate the launch of several innovative new products to assist you in your lab work. We want to help you achieve more in the year to come. Celebrate with Holiday Discounts on GDN and Morpheus screens.


Learn more about the increasing number of ways that GDN (glyco-diosgenin) is being used
as an effective synthetic drop-in substitute for Digitonin, including three recent publications.

Take advantage of our limited time promotions on the purchase of GDN here.


For the past two years, we’ve been telling you about the profound effect Cryo-EM has had on membrane protein structural biology. This impact has never been more obvious than in 2018, as 43 unique membrane protein structures have already been deposited to date as a result of using Cryo-EM – most of which are ion channels belonging to the TRP family. To help simplify the ever-expanding Cryo-EM world for you, we’ve updated our annual compilation table created to reflect the most recent structures of membrane proteins determined by Cryo-EM and the detergents and non-detergent systems used in those experiments. Check out our new Cryo-EM workflow page to learn about all the tools we have to support your Cryo-EM experiments. 


We are pleased to introduce the development of our own version of DIBMA as a sodium salt, an alternative to detergents for the solubilization and purification of membrane proteins. Purified using our own proprietary and extremely stringent methods, then subjected to rigorous quality control tests, our new copolymer can be used directly without any additional hydrolysis, dialysis, or purification. This dramatically improves reproducibility, saving you time and effort in the lab.


The past year has certainly been extremely exciting with the continuing integration of the market leader in detergents and lipids, Anatrace, with the market leader in protein crystallization, Molecular Dimensions. In May, 2018 our parent company, CalibreScientific, completed the acquisition of Protein Ark and BioServUK. Protein Ark specializes in developing tools for protein preparation and purification. BioServUK is a specialist contract research and manufacturing organization with 
expertise in the production and processing of bio-molecules. We are exicted to celebrate our continually growing organization to support all aspects of your protein structural biology research and we would like to extend a special offer to you! Click here for more information.

JULY 2018

Learn about PMALs, the newest class of Amphipols which we have developed in collaboration with Vanderbilt’s Charles Sanders. PMAL is zwitterionic, and contains repeating units of a carboxyl, ammoniumamidate, and alkyl chain. This difference has facilitated some recent and significant determinations in Cryo-EM studies.   

JUNE 2018

We created our Crystallization Screen Redundancy poster to help you quickly choose a set of screens that covers the most chemical space, and reduce redundancy. If you already have your favorite set of initial screens, our poster can also help you identify others that might prove even more effective.

To get a Crystallization Screen Redundancy poster of your own for your lab, just e-mail us.

MAY 2018

We're pleased to introduce our new LMNG:CHS Premixed Solution in our expanding line of premixed solutions. This new mixture takes full advantage of the growing popularity of LMNG mixed with CHS, which was the third most commonly used detergent in 2017 for the solubilization of membrane proteins from their native lipid environment. To learn more information about how our new LMNG:CHS premixed solution can help you reach higher standards in your lab, visit our product page, or contact our customer service team

APRIL 2018

Since its development Lipidic Cubic Phase (LCP) crystallization has been invaluable for the crystallization and structure determination of membrane proteins. Monoolein remains the most commonly used host lipid for LCP. It's often improved with the use of novel additives to increase protein stability and promote crystallization. To save you time and simplify your workflow, we've launched a premixed monoolein:cholesterol (LCP18-CH200).

For a limited time, you can get 5% off your entire purchase (including other detergents) when ordering three products: Our new LCP18-CH200 and P716, along with our existing MonoPalmitolein (LCP16). Click here for more information.

MARCH 2018

In recent years, structural biologists have been switching to GDN as a replacement for Digitonin. This is mostly due to the synthetic nature of GDN, which eliminates batch-to-batch variability. Add to that its >10% solubility in water, a much more attractive price point, and its use in determining three new Cryo-EM membrane protein structures in 2017 (PDB: 5VAI, 6B2Z, 6BPZ). We are also happy to offer a new 25 gram pack size of GDN, which offers significant savings over our smaller pack sizes. Additionally we’re offering a 5% discount on any purchase of 100 GM of GDN.


2017 was a year of accomplishment in the area of membrane protein research. From the structure determination of the MRP1 multi-drug resistance protein and the ABCA1 lipid exporter, to the first Cryo-EM structure of a GPCR (which is also the first full-length structure of a Class B GPCR), there were many novel structures published in 2017. In fact, 63 unique membrane structures were deposited last year alone. Bringing the overall total to 735!

Take a look at our findings to compare detergent usage trends over the years and get yourself ready for a whole new year of higher standards by clicking here



This month we are celebrating all that has been accomplished in 2017. Higher standards in many areas of structural biology have been set, from crystallizing the LRRK2 protein on the International Space Station, to determining the structures of GPR40, TRPV6, and the GLP-1R:peptide complex...not to mention the incredible progress still being made in the field of Cryo-EM

At Anatrace, our year has been equally exciting, as we’ve added Molecular Dimensions to our roster – allowing us to further support the full gene-to-structure pipeline for both membrane and soluble proteins.

We thank you for your business with two special offers. To learn more, click here.


Anatrace is pleased to announce the recent characterization of the alkyl glucoside n-dodecyl-ß-melibioside (ß-DDMB) by Chuck Sanders and his lab at Vanderbilt University. This new detergent differs from traditional DDM in that it contains the disaccharide melibiose instead of maltose as the head group, giving it a slightly higher CMC and smaller micelles. The size of DDMB’s micelles doesn’t change with detergent concentration, temperature, pH, or ionic strength, like it does with DDM. For more information please click here.


The number of protein structures determined by cryo-electron microscopy (Cryo-EM) has increased in just one year by an impressive 46%. Membrane proteins determined by Cryo-EM has grown by an incredible 80% growth. We have compiled a table of the most recent structures for reference, along with the detergents used in their determination. To evaluate which Cryo-EM detergents and tools can help you in your research, please click here.


Researchers sent the Anatrace Microlytic Crystal Formers to the International Space Station to perform microgravity crystallization experiments of the LRRK2 protein. LRRK2 is one of the promising drug targets for the treatment of Parkinson’s disease because mutations in the gene encoding this protein are among the most common genetic causes. 

To find out more about this outer space effort, click here. And to learn how you can support efforts to find a cure for Parkinson’s, visit michaeljfox.org


Anatrace's 30 years in the lab has led to the most commonly used, top-performing, and competitively priced purification resins on the market.

For those involved in affinity purification of poly-histidine tagged proteins through IMAC, we offer our Super-Nickel and Super-Cobalt resins. Our Super-GLU glutathione coupled agarose resin is also a solid performer for those purifying GST-tagged proteins. For immunoglobulin purification, we have our immobilized Protein A and Protein G resins. And for those looking to purify nucleic acid binding proteins, as well as enzymes, hormone receptors, and extracellular matrix proteins, we now offer our new Super Heparin High-Performance Resin. To make things even sweeter, until September 30th, we're offering 10% off your order of purification resins and HiFliQ FPLC Columns.

JULY 2017

The feature this month is the recent publication of two additional structures of the GPR40 protein which identify a novel binding site for full allosteric agonists by Merck Research Laboratories. It furthers the investigation done previously by Amgen and Takeda Pharmaceuticals on the GPR40 receptor. Anatrace was involved in the discovery process with our DDM/CHS pre-made solution and LMNG detergent. And to better understand the progress being made to combat this disease, as well as how Anatrace can help your lab discover innovative solutions for this and much more, click here.

JUNE 2017

We are pleased to introduce our new Biotinylated Amphipol A8-35. We’re giving you another way to help you quickly determine the function of your membrane protein. With a polymer formulation that allows for the immobilization of membrane proteins onto solid supports, our Biotinylated Amphipol A8-35 allows you to do binding assays you typically can’t in detergents without modifying the protein, such as SPR, ELISA and Microscopy. Plus, reconstitution into amphipol is straightforward and simple. 

MAY 2017

Today's labs are finding that fluorinated surfactants are an effective alternative to the use of detergents when working with membrane proteins. Whether it’s improving membrane protein stability, aiding the vitrification process in Cryo-EM, or as an additive in protein crystallization, 
fluorinated surfactants have a number of useful applications for protein biochemistry.

APRIL 2017

This month we are featuring the recent identification of two antibodies with RSV neutralizing activity. Learn about this exciting publication in Nature Communications by the labs of Xavier Saelens at Ghent University and VIB in Belgium and Jason McLellan at Dartmouth College describing the identification of two single-domain antibodies that bind to the protein on the virus that’s essential for infection. A significant part of this study involved elucidating how these antibodies interact with this viral protein. Using the free-interface diffusion method in our Microlytic Crystal Former, co-crystals were obtained with dramatically improved diffraction as compared to those grown using vapor diffusion. 

MARCH 2017

Anatrace now fully supports the entire gene-to-structure pipeline for both soluble and membrane protein targets with the recent addition of the Molecular Dimensions product portfolio to their offering. Molecular Dimensions is the market leader in protein crystallization. The greatest minds in crystallography will now be working together to develop new ideas, new products, and new solutions to continually raise the bar. All of these products will be available through a single source, making future ordering and logistics a breeze.


2016 was an outrageously exciting year for membrane protein research. Nearly 90 unique structures were deposited last year – the most ever. We wanted to share with you our updated data originally created to summarize the detergents most frequently used in 2015's breakthrough studies. Using the current list of unique structures published in 2016 from Steve White's "Membrane Proteins of Known 3D Structure" database, we mined the literature to determine which detergents were most frequently used in membrane protein solubilization, purification, and structure determination experiments. So if you're trying to choose a detergent for your membrane protein solubilization, purification, or structure determination experiments, take a quick look at our updated data.


This month we are highlighting the breakthrough study of the determination of the first structure of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) through the use of single-particle electron cryo-microscopy (cryo-EM). Learn about this groundbreaking step forward by scientists Zhe Zhang and Jue Chen from The Rockefeller University.

2016 Newsletter Graphic


Bringing some holiday cheer to your lab, we thank you for your business and look forward to the excitement next year will bring.


This month, we're highlighting one of the more important ion channel structures involved in critical drug discovery initiatives, ryanodine receptors. While work on determining ryanodine receptor structures has been ongoing, the past 24 months have been especially fruitful thanks to major advancements in the field of single-particle electron cryo-microscopy, as well as breakthrough work.


We know that structural studies of membrane proteins present a number of unique challenges which take a significant investment of time and resources to overcome. By using a pre-crystallization screening assay you’re able to determine the stability of membrane proteins prior to your studies. This month we’ve highlighted some of the commonly used methods for determining the stability of membrane proteins


We are pleased to provide you with an update on the number of atomic-level resolution Cryo-EM structures that have been determined. We’ve compiled a helpful list of the detergents used in the most recent Cryo-EM structures of membrane proteins.


We are committed to providing solutions to the biggest challenge to determining protein structure: Obtaining diffraction-quality crystals. Anatrace offers four winners, including our Microlytic MCSG Suite, Microlytic Top96 Screen, Microlytic PurePEGs Screen, and Analytic Crystallizer.

JULY 2016

We're pleased to announce two new additional classes of detergents: Monopodal Amphiphiles (MPA), and Mannitol-based Amphiphiles (MNA).

June 2016

This month, we're highlighting the recent advancements in the structure determination of glucose transporter (GLUT) proteins.  Learn about the new structures of GLUT1, GLUT3, and GLUT5!

MAY 2016

In order to provide options for bicelle crystallization, Anatrace is excited to offer pre-mixed bicelle solutions of the two most commonly used lipid–detergent combinations.

April 2016

We're excited to officially launch our new line of Trehaloside detergents.

March 2016

Always committed to innovating, this month we launched our newest member of the Neopentyl Glycol family of detergents, Undecyl Maltose Neopentyl Glycol (UMNG).

February 2016

2015 was an exciting year for membrane protein crystallization. Here, we take a look at the structures determined in 2015 and compiled what methods were most often used, as well as what detergents were utilized in solubilization and purification. Not surprising, DDM and DDM:CHS were the clear leaders.

2015 Newsletter Graphic

December 2015

A little holiday cheer!  From the Anatrace team to you, thank you for your business and we wish you a very happy and prosperous new year.

November 2015

Learn about one of our newest detergents, Glyco-diosgenin (GDN), which has shown promise as an effective detergent for the solubilization and stabilization of membrane proteins. Additionally, GDN has been reported as a drop-in substitute for the classic detergent, Digitonin.

September 2015

August 2015

July 2015

June 2015

May 2015

We highlight the very exciting research from Karen Fleming and Emily Danoff at Johns Hopkins University aimed at understanding the factors involved in the folding of β-barrel outer membrane proteins. The results from this work show that the rate of protein folding was directly proportional to the incidences of bilayer defects.

April 2015

This month we officially launch our line of protein purification products! Here, we feature our HiFliQ HPLC columns which are a perfect alternative to HiTrap™ columns. These columns are available in a number of different resin chemistries and are compatible with all FPLC instruments, including ÄKTA™.

March 2015

Learn about the allosteric regulation of Rhomboid Intermembrane Protease as we feature work from the lab of M. Joanne Lemieux at the University of Alberta. In their work, Lemieux and colleagues show that substrate binding and cleavage by the Rhomboid protease AarA  is a multi-step dynamic process requiring multiple steps.

February 2015

In 2011, Anatrace launched a new family of Neopentyl Glycol detergents. Since then, these detergents have been widely successful in the solubilization and stabilization of many classes of membrane proteins. This month, we discuss some of the recent publications utilizing these detergents, as well as focus on some of the properties which make this class of detergents successful.

2014 Newsletter Graphic

October 2014

The past two years have seen a number of novel structures of intermembrane proteases.  Once thought not to exist, structures of these proteins provide valuable insight into how catalysis occurs in active sites embedded in a lipid bilayer. In this newsletter, we highlight some of these recent structures, including, the zinc metalloproteases Ste24p and ZMPSTE24, Human γ-secretase, and the aspartyl protease Presenilin.

September 2014

A major breakthrough in membrane protein structural biology came this year with the first structure of the human glucose transporter GLUT1. Determined by Nieng Yan's group at Tsinghua University in May of 2014, this structure provides insight into how this protein, and other members of the Major Facilitator Superfamily transport substrate. This month, we highlight this research, and discuss some of the technical hurdles that needed to be overcome to determine this structure.

August 2014

A little history lesson....Take a look back to how Anatrace started thirty years ago with the production of high-purity DDM. Since then we have been an leader in the production of innovative detergents such as our CYMAL class, Neopentyl Glycol family, and Anzergent molecules. Additionally, our specialty products, such as Deuterated, Seleniated, and Fluorinated versions of our detergents, have been of great utility to a number of complex research protocols.

July 2014

This month, we take a look at the advancements made in the structure determination of membrane proteins by Cryo-EM. A tool that has become very useful in this endeavor is our new polymer Amphipol A8-35, which provides several advantages over conventional detergents, such as increased stability of proteins, and no free detergent micelles in the sample.

June 2014

As of 2010, only five detergents have been used in the structure determination of over 50% of membrane proteins, even though over 50 detergents have been used in total. In this month's newsletter we discuss some of the methods researchers have adopted to determine the best detergent for your specific membrane protein. One of these methods includes the Differential Filtration Assay which is the backbone of our Analytic Selector Kit.

May 2014

In this newsletter, we introduce our three detergent screening kits which are useful ways to screen detergents, and create a detergent library. Most inclusive are our Master Kits, which contain between 50 and 90 different detergents.  Our Product Group Kits allow for the screening of many detergents within one family (e.g... Maltosides).  Lastly, our Popular Product Kits contain six of our most popular detergents.